Dianthus
A plate-based, microfluidics-free affinity screening platform that provides fast, in-solution binding data using advanced fluorescence-based methods, spectral shift, and TRIC for drug discovery campaigns.
-Plate-based screening (384-well)—microfluidics-free, automation-friendly format for high throughput.
-Two complementary biophysical modalities: Spectral Shift and Temperature Related Intensity Change (TRIC) for precise affinity measurement.
-Wide affinity range: from picomolar (pM) to millimolar (mM).
- Fast data collection: up to 384 data points in ~33 min (Spectral Shift alone) or ~79 min with both methods.
-Low sample consumption: ~20 µL per well.
-Solution works (no immobilization): reduces artifacts and better mimics native conditions.
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Description
The Dianthus system is an affinity screening instrument designed to accelerate drug discovery by providing reliable in-solution binding data without the need for immobilization or complex microfluidics. It uses two fluorescence-based approaches—spectral shift for detecting changes in emission spectra upon binding and TRIC for temperature-related intensity change—to quantify molecular interactions such as target-ligand binding, including challenging targets like PROTACs, intrinsically disordered proteins, and fragment libraries.
Specifications
Biophysical modalities : Spectral Shift and TRIC
Plate format : 384-well, barcoded (seal/rack compatible)
Affinity range : pM to mM
Data points/run : Up to ~384
Run time : ~33 min (Spectral Shift) / ~79 min (both)
Sample volume/well : ~20 µL
Temperature control : 20 – 25 °C ± 0.5 °C
Dimensions : ~61×42×57 cm
Automation support : Integrates with liquid handlers/robots
Application
Dianthus is designed for high-throughput screening and validation in drug discovery workflows, including:
Hit identification and ranking from compound libraries.
Lead validation and optimization with accurate affinity data.
Screening challenging targets such as PROTACs, fragment libraries, and intrinsically disordered proteins.
Integration into automated workflows with robotics and liquid handling systems.