Prometheus Panta C
Advanced, high-precision protein stability and aggregation characterization system suitable for regulated workflows from preclinical research through commercial biopharmaceutical manufacturing.
-Comprehensive stability profiling combining four advanced optical technologies (e.g., nanoDSF, DLS, SLS, and backreflection) for multi-parameter protein characterization.
-High-quality, precise data tailored for biologics developability, process monitoring, and identity characterization.
- Fast, efficient workflow—analyses completed in less than two hours with minimal sample consumption.
-Regulatory compliance support with software features designed to help meet 21 CFR Part 11 data integrity requirements (e.g., user access levels, audit trails).
-Scalable for preclinical research to commercial manufacturing and compatible with LIMS and automation platforms.
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Description
The Prometheus Panta C is designed for multi-parameter protein stability and developability assessment in both research and regulated biomanufacturing environments. It collects data on protein unfolding, aggregation, and size distribution by combining advanced optical detection principles such as nanoDSF (intrinsic fluorescence), DLS (dynamic light scattering), SLS (static light scattering), and backreflection in a single streamlined workflow. This enables users to characterize thermal and colloidal stability, assess process performance, and conduct identity testing with minimal sample and time. Integrated software supports regulatory compliance and scalable data workflows from early discovery through commercial manufacturing.
Specifications
Measurement Principle : Multi-parameter protein stability analysis (nanoDSF, DLS, SLS, backreflection)
Sample Consumption : Minimal volume micro-capillaries
Data Output : Thermal unfolding, aggregation, and size distribution parameters
Software : Regulatory-ready Prometheus Panta C Software (21 CFR Part 11 compliance)
Workflow Duration : < ~2 hours typical
Application
Prometheus Panta C is used in biopharmaceutical research and production where precise protein stability and aggregation profiling are critical, including:
Developability assessment to select lead biologics with favorable stability profiles.
CMC analytical testing to support chemistry, manufacturing, and control documentation.
Identity (ID) testing and comparability studies between drug substance and reference materials.
Process monitoring during manufacturing scale-up and tech transfer.