MP-SPR NAVI™ 420A Ilves

• 4 independent fluidic channels for simultaneous measurements on a single sensor

• High sensitivity with minimal dead volume for efficient sample utilization

• Fully automated operation with 96- and 384-well plates and 6-vial liquid autosampling

• Real-time, label-free analysis of molecular interactions

• Measures binding affinity and kinetics with high sensitivity

• KineticTitration™ for faster affinity and kinetic measurements, particularly for surfaces that are difficult to regenerate

• Two wavelengths per measurement channel for detecting layer thickness and conformational changes

• Wide angular range of 40°–78°, allowing analysis from small molecules and proteins to nanoparticles and living cells

• PureKinetics™ for obtaining true binding kinetics without requiring a reference channel

• 15–45°C temperature control for controlled measurement conditions

• Compatible with organic solvents

• Supports a broad range of sensor surfaces, including Au, SiO₂, CMD, BND, NTA, and regenerable avidin

The MP-SPR Navi™ 420A ILVES is a fully automated, high-sensitivity 4-channel Multi-Parametric Surface Plasmon Resonance (MP-SPR) instrument designed for real-time, label-free analysis of molecular interactions. Its minimal dead volume and four independent fluidic channels make the system well suited for sensitive interaction studies while helping minimize sample consumption. The instrument is particularly suitable for studying interactions involving small molecules, proteins, lipids, nanoparticles, and other biological or surface-active materials. The 420A ILVES combines automated sample handling with two wavelengths per measurement channel, enabling characterization of binding affinity, kinetics, layer thickness, and conformational changes. Its wide angular measurement range also allows measurements across a broad range of sample sizes, from small organic molecules to nanoparticles and living cells. The system supports KineticTitration™, which enables sequential analyte injections at different concentrations without requiring dissociation or regeneration between every concentration step. This can shorten affinity and kinetic measurements, particularly when regeneration of the sensor surface is difficult.

Molecular Interaction Studies Real-time, label-free characterization of molecular binding, affinity, and kinetics. Small Molecule Research Study interactions between small molecules and proteins, lipids, surfaces, or other biological targets with high sensitivity. Protein & Biopharmaceutical Research Characterize protein–protein, protein–ligand, antibody–antigen, and other biomolecular interactions. Lipid & Membrane Research Investigate interactions involving lipid layers, membrane-related systems, and biomolecular surfaces. BioNavis specifically highlights the 420A ILVES for applications involving lipids and molecular interactions. Nanoparticle Research Analyze nanoparticle–surface and nanoparticle–biomolecule interactions. The 420A ILVES is also one of the BioNavis systems recommended for extracellular vesicle studies, where small sample volumes are particularly useful. Biosensor Development Characterize recognition interactions and functionalized sensor surfaces without fluorescent or radioactive labels. Drug Discovery & Biopharmaceutical Development Evaluate binding affinity and kinetics of drug candidates and biological targets. Biophysics Study molecular binding mechanisms, surface interactions, and conformational changes. Living Cell Research Investigate cell–surface interactions and cellular adhesion using compatible measurement configurations.