Andromeda X
Next-generation model with Spectral Shift detection for enhanced expression and stability insights.
-Protein expression optimization: Rapidly evaluates expression levels of recombinant proteins directly in crude lysates without purification.
-Thermal stability insights: Provides information on the folded state and thermal stability of proteins during expression screening—something not directly available from traditional methods like SDS-PAGE alone.
-Spectral Shift detection (in Andromeda X): Highly sensitive optics allow detection of subtle expression and stability differences faster and with better data quality.
-Faster than traditional workflows: Delivers expression and stability data much quicker than methods such as SDS-PAGE, FSEC, or FSEC-TS by combining measurements in one assay.
-Improves purification decision-making: Early insights into protein quality help avoid time-consuming failed purifications and reduce rescreening.
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Description
NanoTemper Andromeda is designed to help researchers and production teams monitor and optimize protein expression and stability before committing to purification or downstream workflows. It assesses expression levels directly in crude lysates and reveals information about protein folding and thermal stability that traditional expression assays do not provide. The Andromeda X model incorporates Spectral Shift technology (high-sensitivity spectral optics) to provide enhanced insights into both expression and stability — enabling faster and more informed decisions for recombinant protein production in biopharma and CRO environments.
Specifications
Purpose : Expression optimization & stability screening from cell lysates
Technology Used : Fluorescence-based thermal stability and expression monitoring (Spectral Shift in Andromeda X)
Sample Type : Crude lysates (no purification required)
Data Provided : Expression levels & thermal stability insights
Enhanced Model : Spectral Shift optics in Andromeda X for improved sensitivity
Integration : Works upstream of purification/structural studies
Consumables : Specialized capillaries and labeling kits available
Application
Andromeda is designed to support:
Recombinant protein production screening—find optimal expression systems and induction conditions.
Protein folding assessment—determine whether expressed proteins are properly folded in lysates.
Thermal stability profiling during expression—measure stability differences among expression conditions before purification.
Accelerated workflow—enables faster decision-making for expression optimization compared to conventional methods like SDS-PAGE or FSEC-TS.