Dianthus uHTS
Ultra-high-throughput biophysical affinity screening platform enabling fast solution-based binding measurements in a 1536-well format.
-Ultra-High Throughput Screening: Measures an entire 1536-well plate in ~8 minutes, enabling screening of large libraries at unprecedented speed.
-Spectral Shift Technology: Uses a breakthrough Spectral Shift method that requires only one labeled binding partner and works in solution, without immobilization.
-Automatable & Integration-Ready: Fully compatible with automation systems and delivers data in easily integrable formats.
-Broad Affinity Range: Detects binding affinities from picomolar to millimolar, capturing both weak and strong binders.
-Low Sample Consumption: Conserves valuable protein targets and compound libraries due to minimal required volumes.
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Description
Dianthus uHTS is the latest evolution of NanoTemper’s Dianthus affinity screening technology optimized for ultra-high-throughput drug discovery campaigns. It measures molecular interactions in solution using Spectral Shift detection in a 1536-well plate format, completing entire plates in under 10 minutes. This enables scientists to screen massive libraries of compounds (e.g., small molecules, peptides) quickly and detect binders without needing prior knowledge of specific binding sites or immobilizing targets. Automated workflows with minimal maintenance allow for constant 24/7 operation.
Specifications
Plate Format : 1536-well plate (ultra-HTS)
Measurement Time : ~8 minutes per full plate
Detection Technology : Spectral Shift in Solution
Affinity Range : pico- to millimolar
Automation Support : Open gRPC framework
Sample Type : Solution phase, labelled partner
Application
Dianthus uHTS is designed for large-scale drug discovery screening workflows such as:
Primary hit identification from massive libraries of small molecules or fragments.
Lead validation and ranking using consistent Spectral Shift data.
Screening under conditions where binding sites are unknown or multiple.
Integration into automated workflows with robotics for continuous 24/7 operation.